AUTHOR=Yang Yiping , Huang Xiaopei TITLE=Targeting Co-Stimulatory Pathways in Gene Therapy JOURNAL=Frontiers in Microbiology VOLUME=2 YEAR=2011 URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2011.00202 DOI=10.3389/fmicb.2011.00202 ISSN=1664-302X ABSTRACT=

Gene therapy with recombinant viral vectors such as adenovirus and adenovirus-associated virus holds great promise in treating a wide range of diseases because of the high efficiency with which the viruses transfer their genomes into host cells in vivo. However, the activation of the host immune responses remains a major hurdle to successful gene therapy. Studies in the past two decades have elucidated the important role co-stimulation plays in the activation of both T and B cells. This review summarizes our current understanding of T cell co-stimulatory pathways, and strategies targeting these co-stimulatory pathways in gene therapy applications as well as potential future directions.