AUTHOR=Schuelein Ralf , Ang Desmond , van Driel Ian R., Hartland Elizabeth L.

TITLE=Immune Control of Legionella Infection: An in vivo Perspective

JOURNAL=Frontiers in Microbiology

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2011.00126

DOI=10.3389/fmicb.2011.00126

ISSN=1664-302X

ABSTRACT=<p><italic>Legionella pneumophila</italic> is an intracellular pathogen that replicates within alveolar macrophages. Through its ability to activate multiple host innate immune components, <italic>L. pneumophila</italic> has emerged as a useful tool to dissect inflammatory signaling pathways in macrophages. However the resolution of <italic>L. pneumophila</italic> infection in the lung requires multiple cell types and abundant cross talk between immune cells. Few studies have examined the coordination of events that lead to effective immune control of the pathogen. Here we discuss <italic>L. pneumophila</italic> interactions with macrophages and dendritic cell subsets and highlight the paucity of knowledge around how these interactions recruit and activate other immune effector cells in the lung.</p>