AUTHOR=Ahmer Brian M., Gunn John S.

TITLE=Interaction of Salmonella spp. with the Intestinal Microbiota

JOURNAL=Frontiers in Microbiology

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2011.00101

DOI=10.3389/fmicb.2011.00101

ISSN=1664-302X

ABSTRACT=<p><italic>Salmonella</italic> spp. are major cause of human morbidity and mortality worldwide. Upon entry into the human host, <italic>Salmonella</italic> spp. must overcome the resistance to colonization mediated by the gut microbiota and the innate immune system. They successfully accomplish this by inducing inflammation and mechanisms of innate immune defense. Many models have been developed to study <italic>Salmonella</italic> spp. interaction with the microbiota that have helped to identify factors necessary to overcome colonization resistance and to mediate disease. Here we review the current state of studies into this important pathogen/microbiota/host interaction in the mammalian gastrointestinal tract.</p>