AUTHOR=Anand Paras K., Malireddi R.K. Subbarao , Kanneganti Thirumala-Devi 

TITLE=Role of the Nlrp3 Inflammasome in Microbial Infection

JOURNAL=Frontiers in Microbiology

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2011.00012

DOI=10.3389/fmicb.2011.00012

ISSN=1664-302X

ABSTRACT=<p>The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1β and IL-18. In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial, and viral infections.</p>