AUTHOR=Kojima Yoshitsugu , Ryo Akihide 

TITLE=Pinning Down Viral Proteins: A New Prototype for Virus–Host Cell Interaction

JOURNAL=Frontiers in Microbiology

VOLUME=1

YEAR=2010

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2010.00107

DOI=10.3389/fmicb.2010.00107

ISSN=1664-302X

ABSTRACT=<p>Pin 1 is an enzyme that specifically catalyzes the <italic>cis–trans</italic> isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins. Recent studies demonstrate that stability of several viral proteins is regulated by phosphorylation-dependent prolyl-isomerization by a host factor Pin1. Pin1 is now positioned as an important modulator of the molecular crosstalk between virus and host cells and could be a unique target for anti-virus therapy. This new type of post-translational modification by Pin1 might be involved in the regulation of other viral proteins.
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