EDITORIAL article
Front. Med.
Sec. Nephrology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1615283
This article is part of the Research TopicWhen The Drug Induces Kidney Diseases: Nephrotoxicity and Intoxication/PoisoningView all 5 articles
When The Drug Induces Kidney Diseases: Nephrotoxicity and Intoxication/Poisoning
Provisionally accepted
- 1Faculty of Medicine, Sao Paulo State University, Botucatu, Brazil
- 2Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo, Brazil
- 3University of California San Diego, Division of Nephrology and Hypertension, Department of Medicine, San Diego, United States
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exposures, predominantly vancomycin, iodinated contrast, and aminoglycosides. While these DI-AKI cases demonstrated lower mortality compared to other AKI etiologies, the need for acute kidney replacement therapy (AKRT) was similar.These findings support growing interest in the development of bundle care strategies for DI-AKI that may mitigate the severity and long-term impact of these events. For example, as discussed by Colares et al., even Recent studies emphasize the need for standardized clinical and histopathologic criteria and suggest that early diagnosis and minimal fibrosis are associated with better outcomes (8,9). Noninvasive diagnostic tools are under investigation, including gallium-67 scintigraphy and the lymphocyte transformation test (LTT), which may help identify AIN and its causative agents, particularly in patients on immunotherapy (10,11). Biomarkers are also gaining traction. Moledina and colleagues (9) identified urinary cytokines, particularly TNF-α and IL-9, as promising diagnostic markers for AIN in a prospective study. These markers outperformed clinical suspicion and standard laboratory parameters in distinguishing AIN from acute tubular injury (ATI) and other AKI subtypes.The evidence presented across this issue reinforces the need for comprehensive epidemiological studies that address the heterogeneous phenotypes and outcomes of DI-AKI. There is increasing momentum behind the development of
Keywords: kidney disease, drug, nephrotoxicity, Acute Kidney Injury, Poisoning
Received: 21 Apr 2025; Accepted: 24 Apr 2025.
Copyright: © 2025 Zamoner, Oliveira and Macedo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Welder Zamoner, Faculty of Medicine, Sao Paulo State University, Botucatu, Brazil
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