94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Med.
Sec. Rheumatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1590102
This article is part of the Research TopicSarcoidosis Diagnosis and Treatment Based on EtiologyView all 5 articles
Phenotyping sarcoidosis: a single institution retrospective analysis
Provisionally accepted
Francesco Bertuccio1,2
Davide Piloni1,2Marianna Russo1,2Fady Tousa1,2Mariachiara Crescenzi1,2Paola Putignano3Nicola Baio3Ida Maragò2
Angelo Guido Corsico1,2
Giulia Maria Stella1,2*- 1San Matteo Hospital Foundation (IRCCS), Pavia, Italy
- 2University of Pavia, Pavia, Lombardy, Italy
- 3Asst Hospital of Crema, Crema, Italy
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Sarcoidosis is a multisystem disease characterized by non-caseating epithelioid cell granulomas. The diagnosis of sarcoidosis is based on compatible clinical presentation, non-necrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative causes of granulomatous disease.[1][2]It is a heterogeneous disease with many focal points to be clarified. For instance, finding a relationship between symptom burden, race, gender, HRQoL, and pulmonary function could have therapeutic ramifications, influence clinical practice, and aid in selecting patients for specific clinical studies. With our analysis, we tried to categorize patients from a single Institution respiratory unit to delineate clinical phenotypes in sarcoidosis. To address this problem and assist in elucidating the differing contributions of genetics, socioeconomic position, environmental exposures, and other sociodemographic variables to illness severity and phenotypic presentation, larger research employing suitable methodology should undoubtedly be conducted. Additionally, the application of transcriptomics, interdisciplinary methods, patients' disease perspectives, and the publishing of novel discoveries may contribute to a better understanding of the pathophysiology of disease and the improvement of clinical support.
Keywords: Phenotyping sarcoidosis: a single institution retrospective analysis sarcoidosis, phenotyping, Interstitial Lung Disease, inflammatory granulomatous diseases, Sarcoidosis, Granulomatous disease
Received: 08 Mar 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Bertuccio, Piloni, Russo, Tousa, Crescenzi, Putignano, Baio, Maragò, Corsico and Stella. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Giulia Maria Stella, University of Pavia, Pavia, 27100, Lombardy, Italy
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.