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SYSTEMATIC REVIEW article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1586742
This article is part of the Research Topic Research on Biomarkers for Immunotherapy in Gastrointestinal Tumors: Basic Exploration and Clinical Application View all articles
Biomarkers used in the diagnosis and prognosis of gastric cancer in young patients: A scientometric analysis
Provisionally accepted
Talshyn Amirkhanovna Nurulla 
Nurbek Kozhakhmetuly Azbergenov *
Saule Zhumabaevna Akhmetova 
Abdiraman Rsalievich Kaliev Aigul Bulatovna Ramankulova Anarzhan Balkashevna Tulyaeva Nurgul Meirimovna Kereeva - West Kazakhstan Marat Ospanov State Medical University, Aktobe, Aktobe, Kazakhstan
Introduction: Gastric cancer in young people is a global health burden, although it is less common than in other age groups. The use of biomarkers is developing in the diagnosis, treatment selection and prognosis of gastric cancer in young patients. In this bibliometric analysis we aim to evaluate the progress of this knowledge, trend topic development and scientific teams and countries involvements in the topic of biomarkers role in gastric cancer in young patients. Methods: The data were obtained from Scopus (536 publications) for the period 1993-2024, all relevant metadata were analyzed using RStudio and Biblioshiny package to perform global trends and hotspots analysis. Results: Publication trends show a constant increase in interest in gastric cancer biomarkers used in the diagnosis and prognosis of gastric cancer in young patients (7.71% per year). The leading countries were China, USA, and Japan, between which there is strong and sustained collaborations. International co-authorship is relatively low (19.4%). The most prolific research centers were Sungkyunkwan University, Sun Yat-sen University, and Fudan University. The most productive researchers were Zhang X., Wang Y., and Li Y. Keywords analysis showed an increase in mentions of topics related to diagnostics (biomarkers, immunohistochemistry), personalized medicine and prognosis. Conclusion: Bibliometric analysis of more than three decades research articles on gastric cancer biomarkers in young patients showed a steady increase, with strong contributions from leading countries and institutions, highlighting the growing focus on diagnostics, personalized medicine, and prognosis.
Keywords: stomach cancer, biomarkers, adults, Young, Immunohistochemistry
Received: 03 Mar 2025; Accepted: 27 Mar 2025.
Copyright: © 2025 Nurulla, Azbergenov, Akhmetova, Kaliev, Ramankulova, Tulyaeva and Kereeva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Nurbek Kozhakhmetuly Azbergenov, West Kazakhstan Marat Ospanov State Medical University, Aktobe, 030019, Aktobe, Kazakhstan
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