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ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1586270
Gender and Age Differences in the Global Burden of Peptic Ulcers: An Analysis Based on GBD 1990-2021 Data
Provisionally accepted- 1Changchun University of Chinese Medicine, Changchun, Jilin Province, China
- 2Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, Hong Kong Region, China
- 3Shenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen, China
- 4Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
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Background Peptic ulcer (PU) is one of the most common gastrointestinal diseases worldwide. With advances in medical technology, the global disease burden of PU has been effectively controlled. However, the most recent evidence regarding the global burden of PU remains limited. Methods Using publicly available data from the Global Burden of Disease (GBD) study from 1990 to 2021, we analyzed the characteristics of the global burden of PU, including trends in incidence, prevalence, mortality, disabilityadjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs). We employed Joinpoint regression, age-period-cohort (APC) analysis, decomposition analysis, and autoregressive integrated moving average (ARIMA) modeling to evaluate changes and influencing factors for each indicator. Results The
Keywords: Global disease burden, Peptic Ulcer, autoregressive integrated moving average model, join-point regression, Age-Period-Cohort analysis
Received: 02 Mar 2025; Accepted: 07 Apr 2025.
Copyright: © 2025 Rui, Zhao, Zhang, Liu, Han, Li, Qi and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhaohui Wang, Shenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen, China
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