REVIEW article
Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1582072
This article is part of the Research TopicAllergic Diseases Through Precision MedicineView all 3 articles
Hypersensitivity reactions to iodinated contrast media: potential mechanisms and clinical management
Provisionally accepted
Xia Zhong
Lihong Zhao*- West China Hospital, Sichuan University, Chengdu, China
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Iodinated contrast media (ICM) are indispensable in modern imaging, but hypersensitivity reactions (HSRs), ranging from mild urticaria to severe anaphylaxis, remain a significant and evolving clinical challenge. Although advancements in ICM formulations and HSR management, ongoing discussions and uncertainties persist, particularly regarding variable epidemiology, complex mechanisms, and debatable clinical management strategies. This review provides a comprehensive overview and insights into the epidemiology, clinical consequences, potential mechanisms, clinical management, and current controversies associated with HSRs to ICM. Ongoing research is critical, focusing on areas such as monitoring epidemiological trends, uncovering underlying mechanisms, improving risk prediction, and refining preventive, diagnostic, and therapeutic strategies. Overall, as the use of ICM continues to rise, balancing their diagnostic benefits with effective management of HSRs is essential to optimizing patient safety and clinical outcomes.
Keywords: Iodinated contrast media, Hypersensitivity reactions, Epidemiology, mechanisms, Clinical Management
Received: 23 Feb 2025; Accepted: 23 Apr 2025.
Copyright: © 2025 Zhong and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lihong Zhao, West China Hospital, Sichuan University, Chengdu, China
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