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SYSTEMATIC REVIEW article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1579112
Therapeutic challenges and new therapeutic targets for Combined Capillary Pulmonary Hypertension： A review
Provisionally accepted- 1 Jilin University, Changchun, Hebei Province, China
- 2 Jilin, Changchun, China
With a high frequency and a poor prognosis, combined pre-and post-capillary pulmonary hypertension (Cpc-PH) is a significant subtype of pulmonary hypertension linked to left-sided heart disease (PH-LHD). The complicated pathophysiology of Cpc-PH is primarily characterized by elevated pulmonary venous pressure leading to an increase in retrocapillary pressure, which is followed by elevated pulmonary artery pressure and a marked rise in pulmonary vascular resistance (PVR). There is currently no well-defined treatment plan for Cpc-PH, and there are numerous obstacles to overcome. In patients with Cpc-PH, the effectiveness of targeted medications for pulmonary hypertension is limited and debatable. Recent research has revealed that the prevalence and progression of Cpc-PH may be influenced by genetic factors, metabolic syndrome, oxidative stress, and fibrosis. To help doctors better manage and treat patients with Cpc-PH, this review provides a detailed description of the disease's epidemiology, pathogenesis, diagnostic techniques, current treatment status, and potential therapeutic targets [1] .
Keywords: Combined pre-and postcapillary pulmonary hypertension (Cpc-PH), Pathophysiological mechanisms, targeted therapy, Current medical and surgical treatments, clinical trials, Pulmonary vascular resistance (PVR)
Received: 18 Feb 2025; Accepted: 03 Apr 2025.
Copyright: © 2025 Lu, Wang, Rong, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weihua Zhang, Jilin, Changchun, China
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