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ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1575887
This article is part of the Research Topic Advances in New Biomarkers for the Diagnosis and Therapy of Gynaecological Tumours View all articles
Performance of HPV Genotyping and GYPC Methylation as a Triage Strategy for HPV-Positive Women with Normal or Minimal Cytological Findings
Provisionally accepted
Saiping Mao 1
Xing Fan 1,2 Li Yang 1 Hongtao Li 3 Dandan Liu 3 Xiaoli He 1* Xiaoli Wang 2* Fang Yu 1*- 1 Changsha Hospital for Maternal and Child Health Care, Changsha, China
- 2 Hunan Normal University, Changsha, Hunan Province, China
- 3 Hunan Hoomya Gene Technology Co., Ltd., Changsha, China
Objective: High-risk human papillomavirus (HR-HPV) screening has increased colposcopy referrals, particularly for women with HR-HPV positivity but no intraepithelial lesions or malignancy (NILM), and those with atypical squamous cells of undetermined significance (ASC-US). A fraction of lowgrade squamous intraepithelial lesions (LSIL) are associated with cervical intraepithelial neoplasia grade 2 or worse (CIN2+) during diagnosis. This study evaluated the ability of GYPC methylation (GYPC m ) to distinguish between
Keywords: cervical screening, Cervical Intraepithelial Neoplasia, GYPC methylation, High-risk human papillomavirus, Absolute risk
Received: 13 Feb 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Mao, Fan, Yang, Li, Liu, He, Wang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoli He, Changsha Hospital for Maternal and Child Health Care, Changsha, China
Xiaoli Wang, Hunan Normal University, Changsha, 410081, Hunan Province, China
Fang Yu, Changsha Hospital for Maternal and Child Health Care, Changsha, China
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