CASE REPORT article
Front. Med.
Sec. Nuclear Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1572900
This article is part of the Research TopicRising Stars in PET and SPECT: 2024View all 4 articles
Late paradoxical intrapulmonary shunt after endoscopic lung volume reduction with endobronchial valves for severe emphysema
Provisionally accepted
- 1Nuclear Medicine Department, Brest University Hospital, Brest, France
- 2Pneumology Department, Brest University Hospital, Brest, France
- 3GETBO, INSERM, UMR1304, Université de Bretagne Occidentale, Brest, Brittany, France
- 4Pneumology Department, Limoges University Hospital, Limoges, France
- 5Pneumology Department, Toulouse University Hospital, Toulouse, France
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Endoscopic endobronchial valve lung volume reduction in the management of severe emphysema reduces volume inflation in the most severely affected areas, with the hope of clinical improvement. We report the case of a patient who presented with late progressive respiratory deterioration following endoscopic endobronchial valve lung volume reduction. Ventilation/perfusion (V/Q)-SPECT/CT showed unexpectedly high perfusion in the atelectasis of the treated lobes, reflecting a paradoxical intrapulmonary shunt. This paradoxical complication of endobronchial valve treatment for severe emphysema is rare and highlights the potential usefulness of performing V/Q-SPECT/CT imaging in patients presenting with respiratory deterioration following endoscopic lung volume reduction.
Keywords: endo-bronchial valves, Endoscopic lung volume reduction (ELVR), Emphysema, ventilation-perfusion SPECT-CT, Lung scintigraphy, Pulmonary shunt
Received: 07 Feb 2025; Accepted: 10 Apr 2025.
Copyright: © 2025 DZUKO KAMGA, GUT GOBERT, EGENOD, GUIBERT and Le Roux. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jacques DZUKO KAMGA, Nuclear Medicine Department, Brest University Hospital, Brest, France
Pierre-Yves Le Roux, Nuclear Medicine Department, Brest University Hospital, Brest, France
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