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CASE REPORT article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1572461
This article is part of the Research Topic New Concepts, Advances, and Future Trends in Clinical Research on Eye Diseases View all 28 articles
Amiodarone-related keratopathy and optic neuropathy -Case report and literature review
Provisionally accepted- 1 The First Affiliated Hospital of Soochow University, Suzhou, China
- 2 Affiliated People's Hospital, Jiangsu University, Zhenjiang, China
- 3 Zhenjiang Kangfu Eye Hospital, Zhenjiang, China
Amiodarone, a highly effective yet lipophilic antiarrhythmic drug with prolonged half-life, is associated with systemic and ocular complications. While keratopathy being the most prevalent, affecting 70-100% of long-term users, amiodarone-associated optic neuropathy (AAON), though rare (incidence: 0.36%-2%), can induce diverse visual impairments, ranging from mild deficits to profound vision loss. Given that patients on amiodarone frequently possess the risk factors of vascular diseases, it is essential to differentiate the diagnosis of AAON from non-arteritic anterior ischemic optic neuropathy (AION). This study reports a 61-year-old man who developed both corneal deposition and optic neuropathy during systemic amiodarone therapy. We further analyze the clinical features of keratopathy and optic neuropathy caused by amiodarone through a comprehensive literature review, aiming to enhance diagnostic recognition and management strategies.
Keywords: Amiodarone, optic neuropathy, Keratopathy, amiodarone-associated optic neuropathy, Anterior ischemic optic neuropathy
Received: 07 Feb 2025; Accepted: 21 Mar 2025.
Copyright: © 2025 Meng, Xia, Gong and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Peirong Lu, The First Affiliated Hospital of Soochow University, Suzhou, China
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