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ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1571631
This article is part of the Research Topic Nutrition in Pancreatic Diseases: The Role of Nutritional Status and Nutrition Therapy in the Management of Pancreatitis and Pancreatic Cancer View all 4 articles
Risk Factors Associated with Acute Pancreatitis in Diabetic Ketoacidosis Patients: a 11-year experience in a single tertiary medical center and comprehensive literature review
Provisionally accepted- 1 The Department of Emergency Medicine, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu Province, China
- 2 The Department of Medicine, Northwest Minzu University, Lanzhou, Gansu Province, China
- 3 Dalian Medical University, Dalian, Liaoning, China
Objective: To identify independent risk factors and predictive markers for acute pancreatitis (AP) in patients with diabetic ketoacidosis (DKA).Methods: Here, we reported a 11-year experience in a single tertiary medical center and conduct a systematic review of acute pancreatitis in diabetic ketoacidosis patients(DKA-AP). 1941 cases were included. First retrospective cohort study analyzed clinical data from 45 patients with DKA-AP and 45 matched controls with DKA alone (DKA-nonAP) admitted to Yangzhou University Affiliated Hospital (2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020)(2021)(2022)(2023)(2024). Baseline characteristics included BMI, hyperlipidemia history, and serological profiles. Secondly we retrieved clinical studies of DKA-AP from PubMed database system and analysed these clinical data in depth.Results: Significant differences were observed in BMI: median [IQR] = 6. 30 [22.15-28.40] vs. 23.20 [20.70-25.35] kg/m² , p = 0.031, hyperlipidemia history (26.7% vs. 4.4%, p = 0.004), abdominal pain duration (3 vs. 0 days, p < 0.001), and lipid profiles TC: median [
Keywords: Diabetic Ketoacidosis, acute pancreatitis, Pancreatitis, Risk factors, diagnosis
Received: 08 Feb 2025; Accepted: 25 Mar 2025.
Copyright: © 2025 Chen, Bo, Han and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yifei Chen, The Department of Emergency Medicine, Affiliated Hospital of Yangzhou University, Yangzhou, 225001, Jiangsu Province, China
Yan Bo, The Department of Medicine, Northwest Minzu University, Lanzhou, Gansu Province, China
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