ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1567232
Clinical Impact of Idiopathic Pulmonary Fibrosis on SARS-CoV-2 Patient Outcomes: A Comprehensive Analysis in the Pre-Vaccination Era
Provisionally accepted
- 1Houston Methodist Hospital, Houston, United States
- 2Jinnah Medical and Dental College, Karachi, Sindh, Pakistan
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Our retrospective study aimed to evaluate the impact of idiopathic pulmonary fibrosis (IPF) on the clinical outcomes of COVID-19 admissions using data from the 2020 nationwide inpatient sample (NIS). Among the 1,018,915 adults hospitalized with COVID-19 in 2020, 910 were also diagnosed with IPF. After multivariate adjustment for baseline demographics and comorbidities, patients admitted with both COVID-19 and IPF had a higher risk of mortality compared to those without IPF (adjusted OR 1.87 [95% CI 1.13-2.70], p<0.01). Additionally, patients with both conditions had higher odds of requiring mechanical ventilation (adjusted OR 1.66 [95% CI 1.13-2.42] p=0.01) and needing mechanical ventilation within the first 24 hours of admission (adjusted OR 1.87 [95% CI 1.013-3.39] p=0.04). IPF patients incurred higher mean total hospitalization charges
Keywords: COVID-19, Idiopathic Pulmonary Fibrosis, outcomes, viral infections, hospitalization, Length of Stay, Hospitalization cost
Received: 26 Jan 2025; Accepted: 23 Apr 2025.
Copyright: © 2025 Tamimi, Safdar, Siddiqui, Nisar and Gotur. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Omar Tamimi, Houston Methodist Hospital, Houston, United States
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