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ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1563889
This article is part of the Research Topic Chronic Atrophic Gastritis: Pathogenesis, Diagnostic Challenges, and Gastric Cancer Risk View all 3 articles
ASSESING GASTRIC CANCER RISK USING THE OLGA AND OLGIM SYSTEMS IN REPUBLIC OF MOLDOVA
Provisionally accepted
Adriana Botezatu 1
Radu-Alexandru Farcas 2*
Simona Grad 2
Dan-Lucian Dumitrașcu 2 Nicolae Bodrug 1
Massimo Rugge 3- 1 Nicolae Testemiţanu State University of Medicine and Pharmacy, Chișinău, Moldova
- 2 University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania
- 3 Department of Medicine DIMED,University Hospital of Padua, Padua, Veneto, Italy
Background: Gastric cancer is still an important public health problem. Efforts have been made to lower its prevalence globally. The Operative Link on Gastritis Assessment (OLGA) and operating link for gastric intestinal metaplasia (OLGIM) histological grading systems have been proposed to identify individuals with types of gastritis that have the potential to become malignant. Aim of the study: Our study was conducted to assess the value of OLGA and OLGIM systems in the diagnosis of gastric precancerous lesions, in the Moldovan population. Methods: In a prospective study, 142 consecutive patients with chronic atrophic gastritis (CAG) from a larger group of patients referred to upper gastrointestinal endoscopy for dyspeptic symptoms or gastric cancer screening was investigated. The sample was divided into three groups: a) CAG without intestinal metaplasia and gastric dysplasia; b) CAG with intestinal metaplasia; c) CAG with gastric dysplasia according to the morphological type of the lesion. GastroPanel biomarkers were correlated with OLGA and OLGIM stages.Results: There was a direct, moderate and statistically significant correlation between types of CAG and OLGA stages (p <0.001), a direct, weak and statistically significant correlation between forms of chronic atrophic gastritis and OLGIM stages (p<0.001). A statistically significant reduction in Pepsinogen I and the Pepsinogen-I/Pepsinogen-II ratio was observed alongside an increase in the stages of the OLGA and OLGIM systems. Conclusions: OLGA and OLGIM systems are useful tools in diagnosing CAG. This is the first study assessing the use of this systems in the Moldovan population.
Keywords: Chronic atrophic gastritis, intestinal metaplasia, OLGA/OLGIM, gastric cancer, Gastric dysplasia
Received: 20 Jan 2025; Accepted: 27 Feb 2025.
Copyright: © 2025 Botezatu, Farcas, Grad, Dumitrașcu, Bodrug and Rugge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Radu-Alexandru Farcas, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania
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