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ORIGINAL RESEARCH article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1561255
The Value of NLR, PLR, PCT, and D-D Levels in Assessing the Severity of Hyperlipidemic Acute Pancreatitis
Provisionally accepted- 1Jining First People's Hospital, Jining, China
- 2Weihai Central Hospital, Weihai, Shandong, China
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The incidence of hyperlipidemic acute pancreatitis (HLAP) has been increasing yearly, presenting a younger demographic and high mortality rates. Early assessment of severity is essential for improving treatment strategies and outcomes. Various serum biomarkers, including neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have shown prognostic value in inflammatory conditions.Objective: This study aims to evaluate NLR, PLR, procalcitonin (PCT), and D-dimer (D-D) as biomarkers in assessing HLAP severity, identify independent predictors factors for moderate-tosevere HLAP, and provide evidence for tailored therapeutic interventions.: A retrospective analysis was conducted on 145 HLAP patients admitted between mid-2021 and mid-2023 at Jining No. 1 People's Hospital. Patients were categorized into mild HLAP and moderate-to-severe HLAP groups based on severity. Clinical and biochemical data were analyzed using SPSS 26.0, and the diagnostic efficacy of NLR, PLR, PCT, and D-D was evaluated via Receiver Operating Characteristic (ROC) curve.Results: Elevated levels of NLR, PLR, PCT, and D-D were identified as independent predictors for moderate-to-severe HLAP. The combined ROC curve for these biomarkers yielded an Area Under the Curve (AUC) of 0.898 (95% CI: 0.841-0.956), with sensitivity and specificity of 0.818 and 0.892, respectively, outperforming individual biomarkers.The combined assessment of NLR, PLR, PCT, and D-D is a simple, efficient, and costeffective method for early HLAP severity evaluation. Further large-scale studies are warranted to validate these findings.
Keywords: HLAP, platelets, Neutrophils, Lymphocytes, PCT, D-D, Severity assessment
Received: 15 Jan 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Pan, Xiao and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li-juan Fan, Jining First People's Hospital, Jining, China
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