Editorial: Tumor Microenvironment and Personalized Therapy of Gastrointestinal Cancer

Xinxin Wang ^1,2* Jianming James Tang ³ Shuang Yang ¹ Shuo Li ^1,2

• ¹ School of Medicine, Nankai University, Tianjin, China
• ² General Surgery Department, the First Medical Center of Chinese PLA General Hospital, Beijing, China
• ³ Department of Medicine/Division of Infectious Diseases, University of Alabama at Birmingham (UAB) Schools of Medicine, Birmingham, United States

The present Research Topic focused on the clinical practice of immunotherapy and molecular targeted therapy in gastrointestinal cancer. It aimed to dissect the tumor microenvironment and establish robust methods for predicting efficacy, providing a theoretical foundation to enhance the prognosis and quality of life for patients with gastrointestinal cancer. Gambella et al. conducted a comprehensive evaluation of YKL-40 levels in a multicenter cohort of 72 patients diagnosed with anal squamous cell carcinoma. They utilized immunohistochemistry staining to assess YKL-40 expression in both tumor cells and peritumor immune cells within surgical resection specimens. Additionally, they analyzed the serological levels of YKL-40 at the time of diagnosis and during follow-up visits. The findings indicated promising prospects for YKL-40 as both a prognostic marker based on serum levels and a predictive marker associated with tissue protein expression in peritumor immune cells for anal squamous cell carcinoma.Liu et al. performed a multi-omics analysis incorporating bulk RNA sequencing, single-cell RNA sequencing, and whole-exome sequencing to explore the tumor microenvironment of left-sided (LCC) and right-sided colon cancer (RCC). Results revealed significant differences in immune cell infiltration between LCC and RCC. Whole-exome sequencing identified a notably higher mutation frequency in RCC compared to LCC. Single-cell analysis highlighted RCC-specific tumor cell subclusters, alongside CD8+ T cell populations in RCC showing exhaustion and recent activation, indicative of tumor-specific cytotoxic T lymphocytes (CTLs). Furthermore, intercellular communication analysis showed more frequent and intense interactions between tumor-specific CTLs and tumor cells in RCC.Cui et al. undertook a study involving 177 patients undergoing neoadjuvant chemotherapy and immunotherapy followed by gastrectomy. Uni-and multivariable logistic regression models identified risk factors for postoperative complications, and a predictive nomogram was developed. Significant risk factors included age ≥ 70 years, higher blood loss, platelet/lymphocyte ratio ≤ 196, neutrophil/lymphocyte ratio > 1.33, non-R0 resection, and body mass index < 18.5 kg/m². The nomogram, based on these factors, demonstrated strong predictive performance and good calibration.Pelosi et al. analyzed the metabolome composition of the secretome in a three-dimensional coculture model of colorectal cancer (CRC) and adipocytes. This approach, integrating advanced biological techniques, marked a significant step forward in understanding CRC-adipocyte interactions. The study identified key lipids (PG 20:0, 11Z-Octadecenal, 9,10-Dihydroxy-12Zoctadecenoic acid, Palmitoleic acid, PA 18:4) and an amino acid derivative (Acetylglutamic acid), providing insights into potential biomarkers and the underlying mechanisms of CRC-adipocyte crosstalk.Tong et al. studied clinicopathological features and follow-up data of a retrospective cohort of 1,757 cases of stage 0-IV colorectal cancer and revealed significant differences in certain clinicopathological features. The sCEA, tCEA, and combined CEA demonstrated prognostic value in stages III-IV of CRC, with only combined CEA acting as an independent prognostic factor in these stages. Therefore, combined CEA might be considered a novel indicator for evaluating CRC prognosis.