Efficacy and safety of dupilumab in patients with moderateto-severe atopic dermatitis and comorbid allergic rhinitis

Tengfei Tian ^1* Yueguang Li ^2,3 Guangmei Yuan ⁴ Wenxiu Jiang ¹

• ¹ Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, Shanghai Municipality, China
• ² Department of Burns and Plastic Surgery, Zhongda Hospital, Southeast University, Nanjing, China
• ³ Department of Dermatology, Zhongda Hospital, Southeast University, Nanjing, China
• ⁴ Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, Shandong Province, China

Objective: To examine the efficacy and safety of dupilumab treatment in moderate-tosevere atopic dermatitis (AD) patients with comorbid allergic rhinitis (AR).Methods: A total of 26 patients received subcutaneous dupilumab every 2 weeks and were followed up for 16 weeks. The efficacy assessment was evaluated based on clinical parameters every four weeks, including the Eczema Area and Severity Index (EASI), Pruritus Numeric Rating Scale (P-NRS), Severity Index (EASI), and Dermatology Life Quality Scale (DLQI) for the severity of AD symptoms, and the total nasal symptom scores (TNSS), visual analogue scale (VAS) and Mini Rhinoconjunctivitis Quality of Life Questionnaire (MiniRQLQ) for the severity of AR symptoms. The serum total immunoglobulin E (IgE) and eosinophil levels were collected at baseline and 16 weeks after dupilumab treatment. Treatment-emergent adverse events (TEAEs) ware conducted to evaluate the safety profile of dupilumab.Results: Dupilumab treatment resulted in a significant improvement in AD symptoms after 16 weeks as demonstrated by reduced EASI, NRS, DLQI, and ADCT scores.In addition, dupilumab treatment had a significant improvement in AR symptoms based on reduced TNSS, VAS and MiniRQLQ scores. After 16 weeks of dupilumab treatment, the blood eosinophil count, eosinophil percentage, and total serum IgE levels were significantly decreased when compared with the baseline values (P < 0.01 both). During the treatment period, the incidence of TEAEs was 13.77% (n = 8). The most commonly reported TEAEs were injection-site reactions (n = 13, 60.25%), Conclusions: Dupilumab treatment resulted in clinically relevant improvements in symptoms of AD and AR and had an acceptable safety profile.