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CASE REPORT article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1556735
Diagnosis of Tropheryma Whipplei Pneumonia Using Targeted Nanopore Sequencing: A Rare Case Report and Literature Review
Provisionally accepted
Miao Yu1*
Wenbin Wang2
Wei Chen2
Kexin Ye2
Yuqing Zhou2Deep K. Vaishnani2Chen Chen2
Xauancheng Jin2Xiaojun Zhu3
Jun Ma4Fengfei Qian1Xiaohua Zhong1Chuanhua Nie1- 1Hangzhou linping hospital of interated traditional Chinese and Western medicine, Hangzhou, China
- 2Wenzhou University, Wenzhou, Zhejiang Province, China
- 3rui'an people's hospital, Wenzhou University, Wenzhou, Zhejiang Province, China
- 4First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
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Tropheryma whipplei (TW) pneumonia is a rare disease caused by Tropheryma whipplei infection. Due to the difficulty in obtaining pathogenetic evidence, the misdiagnosis rate is high, posing significant 2 challenges for early diagnosis and treatment. Targeted sequencing technology based on nanopore sequencing technology (tNGS) allows for detecting rare pathogens that are difficult to identify using traditional methods, leading to improved detection rates for TW. This paper reports a case of pneumonia diagnosed as a TW infection through the use of tNGS on bronchoalveolar lavage fluid (BALF), with the patient showing improvement after treatment with sequential administration of meropenem followed by compounded sulfamethoxazole.
Keywords: Tropheryma whipplei, Pneumonia, TNGS, nanopore sequencing, BALF, case report
Received: 07 Jan 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Yu, Wang, Chen, Ye, Zhou, Vaishnani, Chen, Jin, Zhu, Ma, Qian, Zhong and Nie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Miao Yu, Hangzhou linping hospital of interated traditional Chinese and Western medicine, Hangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.