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CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1556041
Successful treatment of pulmonary hypertension due to HIV infection and amphetamine snorting: A case report
Provisionally accepted- China Medical University, Shenyang, China
HIV infection is one of the high-risk factors for pulmonary hypertension (PH). HIV-related PH is associated with non-AIDS-related comorbidities. In this study we report a case of pulmonary hypertension with several concomitant risk factors, who experienced a complete clinical improvement after drug rehabilitation, application of anti-retroviral therapy (ART) and Sildenafil.A 37-year-old HIV-positive man complained about worsening dyspnea was diagnosed with severe PH. PH in this case was characterized by association with multi-factors including amphetamine inhalation, HIV infection, bacterial liver abscess, history of splenectomy and past ventricular septal defect, which was different from previously reported HIV-related PH cases who were associated solely to HIV infection. Our case intends to raise awareness that PH should be suspected among HIV-positive patients with unexplained dyspnea. Notably, investigating the co-existent risk factors and a multidisciplinary team are crucial for early diagnose and better prognosis of HIV-related PH.
Keywords: pulmonary hypertension, HIV infection, Amphetamine, sildenafil, anti-retroviral therapy
Received: 06 Jan 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Sun, Wen and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Wen, China Medical University, Shenyang, China
Yanli Chen, China Medical University, Shenyang, China
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