Chest radiographs in acute respiratory distress syndrome (ARDS): An Achilles' heel of the Berlin criteria?

Miguel Bardají-Carrillo ^1,2,3 Marta Martín-Fernández ^1,3,4 Rocío López-Herrero ^1,2,3,5* Juan M Priede-Vimbela ^1,2,3 Irene Arroyo-Hernantes ^1,6 Esther Gómez-Sánchez ^1,2,3,5 Jesús Villar ^7,8 Eduardo Tamayo ^1,2,3,5

• ¹ Biocritic, Group for Biomedical Research in Critical Care Medicine, Valladolid, Spain
• ² Anesthesiology and Critical Care, Clinical University Hospital of Valladolid, Valladolid, Spain, Valladolid, Spain
• ³ Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain, Madrid, Spain
• ⁴ Department of Medicine, Toxicology and Dermatology, University of Valladolid, Valladolid, Spain, Valladolid, Spain
• ⁵ Department of Surgery, University of Valladolid, Valladolid, Spain, Valladolid, Spain
• ⁶ Clinical University Hospital of Valladolid (HCUV), Department of Research and Innovation, SACYL/IECSCYL, 47003 Valladolid, Spain, Valladolid, Spain
• ⁷ Research Unit, Hospital Universitario Dr. Negrín, Barranco de la Ballena s/n, 4th Floor-South Wing, 35019, Las Palmas de Gran Canaria, Spain., Las Palmas de Gran Canaria, Spain
• ⁸ Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada

Background: Despite the high mortality and economic burden associated with the acute respiratory distress syndrome (ARDS), the role of chest radiograph (CXR) in ARDS diagnosis and prognosis remains uncertain. The purpose of this study is to elucidate clinical characteristics that distinguish ARDS patients from those without ARDS, especially in patients where CXRs are indicative of ARDS.Methods: Secondary analysis of a prospective observational study with 454 postoperative septic patients under mechanical ventilation (MV). Patients were stratified in two groups depending on whether they met the Berlin criteria for ARDS. Primary outcome was identification of clinical characteristics differentiating patients with ARDS confirmed by CXR from non-ARDS patients. Secondary outcome was 60-day in-hospital mortality of postoperative sepsis-induced ARDS.Results: 139 patients (30.6%) had CXRs compatible with ARDS, although ARDS was confirmed in only 45 patients (9.9%). Emergency surgery (OR 6.6), abdominal source of infection (OR 6.0), pneumonia (OR 8.2), and higher lactate (OR 3.9) were clinical features associated with ARDS development confirmed by CXR. ARDS was an independent risk factor for 60-day mortality (OR 1.8).Although CXR criteria for ARDS diagnosis could be replaced in future definitions, its importance for ARDS diagnosis should not be underestimated.