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CASE REPORT article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1552050
This article is part of the Research TopicSepsis Awareness Month 2024View all articles
Case report: complete recovery of patient with occult septic shock following supranormal vasopressor and inotrope therapy informed by the novel 'pressure field method' for managing hemodynamics
Provisionally accepted
Stephen F Woodford1*
Ruth C Marshall2- 1Austin Health, University of Melbourne, Melbourne, Australia
- 2Austin Health, Melbourne, Australia
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Complete recovery of a patient with occult septic shock and left ventricular ejection fraction of 10% was achieved following management informed by continuous measurement and visualization of the patient's 'pressure field'. The 'pressure field' visualizes mean perfusion pressure as the product of stroke volume and a beat-to-beat measure of vascular tone termed systemic elastance. The pressure field informed titration of inotropes and vasopressors at high doses, including norepinephrineequivalents >2.5 µg/kg/min, with the goal of restoring the patient's estimated pre-morbid pressure field values. Urine output was maintained throughout with no ileus. We hypothesize pressure field management assists in individualizing care for patients with septic shock and improves outcomes.
Keywords: Pressure field, septic shock, Elastance, Perfusion, personalized hemodynamics, Norepinephrine
Received: 27 Dec 2024; Accepted: 08 Apr 2025.
Copyright: © 2025 Woodford and Marshall. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Stephen F Woodford, Austin Health, University of Melbourne, Melbourne, Australia
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