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REVIEW article
Front. Med.
Sec. Gene and Cell Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1550901
This article is part of the Research Topic Tipping the Balance: DNA Replication and Repair Vulnerabilities in Cancer View all articles
The Multifaceted Functions of SPC25 in Cancer: From Molecular Pathways to Targeted Therapy
Provisionally accepted
Yigang Jin Minjie Chen Fei Chen Zhaofeng Gao Xiaoping Li 
Lingyu Hu Dandan Cai 
Siqi Zhao 
Zhengwei Song *- Jiaxing University, Jiaxing, China
Spindle Pole Body Component 25 (SPC25), a critical component of the NDC80 kinetochore complex, plays an essential role in maintaining chromosomal stability during mitosis. Recent studies have revealed its aberrant expression in various cancers, highlighting its potential as both a diagnostic biomarker and a therapeutic target. This review provides a comprehensive analysis of the molecular mechanisms underlying SPC25's involvement in tumorigenesis, including its regulation of cell cycle progression and interaction with key oncogenic pathways. Furthermore, we discuss its prognostic significance across different cancer types and its potential impact on therapy resistance. The emerging evidence underscores SPC25's multifaceted role in cancer biology, offering novel insights into its clinical applications. We conclude by exploring future research directions, emphasizing the need for in-depth studies to unravel the precise molecular functions of SPC25 and its therapeutic potential in cancer treatment.
Keywords: SPC25, Cancer Progression, biomarker, Therapeutic target, Ndc80 complex
Received: 24 Dec 2024; Accepted: 04 Apr 2025.
Copyright: © 2025 Jin, Chen, Chen, Gao, Li, Hu, Cai, Zhao and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhengwei Song, Jiaxing University, Jiaxing, China
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