SYSTEMATIC REVIEW article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1547850
This article is part of the Research TopicTargeted Therapies in Gastric Cancer: Molecular Signatures and Immune Microenvironment InsightsView all 10 articles
Bibliometric analysis of tumor marker application in gastric cancer diagnosis from 2019 to 2024
Provisionally accepted
Zhanat Komekbay1*
Reza Shirazi2Gulnaz Yessultanova1Alisher Garifollin1Anar Tulyayeva1Nurgul Kereyeva1
Saule Akhmetova1Abdiraman Kaliev1- 1West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
- 2University of New South Wales, Sydney, Australia
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Gastric cancer remains a significant global health challenge, ranking fifth worldwide in both incidence and mortality worldwide. Early detection and accurate prognosis are crucial for effective management, yet current diagnostic methods, including tumor markers, often exhibit less sensitivity. This bibliometric analysis investigates trends and key contributions in research on tumor markers for gastric cancer diagnosis from 2019 to 2024. Using Scopus and Web of Science databases, 2,940 articles were analyzed to assess publication trends, prominent authors, institutions, and emerging research themes. Results highlight East Asia, particularly institutions like Fudan University and Nanjing Medical University, as a hub for groundbreaking research. The study identifies key tumor markers and advances in molecular diagnostics, with emphasis on personalized medicine and early detection strategies. Visualization of global collaborations reveals extensive networks driving innovation in this field. While this analysis underscores progress in gastric cancer biomarker research, it also identifies limitations, including language bias and a narrow temporal scope. Future research should prioritize novel biomarkers, integrate advanced technologies like AI, and enhance international cooperation to further improve outcomes for gastric cancer patients.
Keywords: Tumor marker, gastric cancer, prognosis, Immunohistochemistry, Diagnosis 1. Introduction
Received: 18 Dec 2024; Accepted: 16 Apr 2025.
Copyright: © 2025 Komekbay, Shirazi, Yessultanova, Garifollin, Tulyayeva, Kereyeva, Akhmetova and Kaliev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhanat Komekbay, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
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