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ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1543665
This article is part of the Research Topic Innovative Approaches to Cholangiocarcinoma: Diagnosis, Treatment, and Multidisciplinary Care View all 4 articles
Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) index in Patients with Intrahepatic Cholangiocarcinoma after Radical Resection
Provisionally accepted- Department of Organ Transplantation Hepatobiliary Surgery, Shandong Provincial Hospital, Jinan, Shandong Province, China
The aim of this study is to explore the prognostic value of CRP-Albumin-Lymphocyte (CALLY) index in patients undergoing radical resection of intrahepatic cholangiocarcinoma (ICC).: Retrospectively collected clinical data of 286 patients with ICC who underwent radical surgery at Shandong Provincial Hospital from July 2010 to July 2021. Univariate and multivariate analyses were used to evaluate the correlation between the CALLY index and overall survival (OS) and recurrence-free survival (RFS), and a nomogram prediction model was established based on the results. The accuracy of the model was evaluated using concordance index (C-index), calibration curves, decision curve analysis (DCA), and the receiver operating characteristic (ROC) curve was used to compare the prognostic value of the nomogram model with the TNM staging system.The optimal cut-off value of CALLY index was 1.81. In the training set, multifactorial Cox regression analysis showed that CALLY index <1.81 was an independent risk factor for OS and RFS (p<0.05). Compared to neutrophil-tolymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and modified Glasgow prognostic score (mGPS), CALLY index had a higher area under the curve (AUC). The nomogram established based on the results of multifactorial analysis demonstrated strong efficacy in survival prediction, and the ROC curve showed that the nomogram had a higher prognostic value than TNM staging.The CALLY index is independently associated with OS and RFS in patients after radical resection of ICC, and the nomogram model based on it shows significantly higher efficacy in predicting the long-term prognosis of patients after radical resection of ICC, and is more accurate than TNM staging.
Keywords: intrahepatic cholangiocarcinoma, Inflammation, nutrition, Immunity, prognosis, nomogram
Received: 13 Dec 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Lang, Kong, Liu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jun Liu, Department of Organ Transplantation Hepatobiliary Surgery, Shandong Provincial Hospital, Jinan, 250021, Shandong Province, China
Guangbing Li, Department of Organ Transplantation Hepatobiliary Surgery, Shandong Provincial Hospital, Jinan, 250021, Shandong Province, China
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