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ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 |
doi: 10.3389/fmed.2025.1542073
This article is part of the Research Topic New Concepts, Advances, and Future Trends in Clinical Research on Eye Diseases View all 15 articles
Association between Systemic Inflammatory Response Index and Glaucoma
Provisionally accepted- 1 Eye Center, Xiamen University, Xiamen, China
- 2 The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
- 3 Chongqing Three Gorges Medical College, Chongqing, China
- 4 Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
- 5 Department of Pharmacy, Shanghai Pudong Hospital, Shanghai, Shanghai Municipality, China
Objective: This study aimed to investigate the association between the Systemic Inflammatory Response Index (SIRI) and glaucoma using data from the 2005–2008 National Health and Nutrition Examination Survey (NHANES).Methods: We performed a cross-sectional analysis using data from NHANES (2005–2008). Among participants who underwent non-mydriatic retinal imaging and Frequency Doubling Technology (FDT) visual field testing, 4,514 were included after excluding those with missing key variable data. SIRI and other inflammatory indices, including the systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR), were calculated from blood samples. Logistic regression models were employed to assess the relationship between these indices and glaucoma, adjusting for demographic and health-related variables.Results: A significant positive association was found between elevated log2SIRI levels and the prevalence of glaucoma (Model 3: OR 1.24, 95% CI 1.07-1.44, p < 0.005). We performed an in-depth analysis of the Log2SIRI quartiles and found a significant association between Log2SIRI Q4 and the occurrence of glaucoma (Model 3: OR1.62, 95%CI 1.12-2.34, p=0.011). This correlation was further validated using the area under the receiver operator characteristic curve (AUC) in Model 3(AUC=0.674). Conclusion: Elevated SIRI levels are significantly associated with the prevalence of glaucoma, highlighting the potential role of systemic inflammation in glaucoma pathogenesis. SIRI may serve as a useful biomarker for identifying individuals at risk of glaucoma, facilitating early detection and targeted intervention strategies. Further research is needed to validate these findings and explore their clinical applications.
Keywords: systemic inflammatory response index (SIRI), Glaucoma, NHANES, systemic inflammation, biomarkers
Received: 09 Dec 2024; Accepted: 16 Jan 2025.
Copyright: © 2025 Li, Sun, Zhong, Zhang, Jiafeng and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tang Jiafeng, Chongqing Three Gorges Medical College, Chongqing, 404120, China
Zhanyang Luo, Department of Pharmacy, Shanghai Pudong Hospital, Shanghai, 200032, Shanghai Municipality, China
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