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ORIGINAL RESEARCH article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 |
doi: 10.3389/fmed.2025.1541745
Clinical Characteristics and Surgical Treatment Comparison of Multisegmental Spinal Tuberculosis: A Retrospective Analysis
Provisionally accepted- 1 Other, General Hospital of Ningxia Medical University, China
- 2 Department of Orthopedic, General Hospital of Ningxia Medical University Yinchuan, Ningxia Hui Autonomous Region, 750004, China, yinchuan, China
Background: To analyze the therapeutic efficacy of intervertebral surgery in the treatment of multisegmental spinal tuberculosis (MSTB) by evaluating its clinical outcomes and perioperative indicators, thereby providing evidence-based insights to optimize surgical strategies and improve clinical decision-making. Methods: This retrospective cohort study analyzed 134 MSTB patients treated at our hospital between January 2000 and June 2022. Based on the surgical approach, patients were divided into two groups: Group A (n = 75), who underwent intervertebral surgery, and Group B (n = 59), who received non-intervertebral surgery. All patients underwent radical debridement, bone graft fusion, spinal canal decompression, and internal fixation to restore spinal alignment. To compare the clinical outcomes of these two surgical approaches, we assessed perioperative parameters, radiographic outcomes, laboratory inflammatory markers, neurological recovery, and complication rates. Statistical analyses included t-tests or Mann-Whitney U tests for continuous variables and Chi-square or Fisher's exact tests for categorical variables.The mean follow-up duration was 63.24 ± 9.16 months for Group A and 64.05 ± 9.74 months for Group B. Group A demonstrated significantly shorter operative time and reduced intraoperative blood loss compared to Group B (P < 0.05). No significant differences were observed between the groups regarding preoperative, 6-month postoperative, and final followup values of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, Cobb angle, or visual analog scale (VAS) scores (P > 0.05). Bone fusion rates were comparable between the two groups at six months, one year postoperatively, and at final follow-up, with complete fusion achieved in all patients (P > 0.05). The incidence of postoperative complications and neurological recovery rates did not differ significantly between the two groups (P > 0.05).Both intervertebral and non-intervertebral surgical strategies for MSTB can effectively restore spinal alignment and achieve satisfactory neurological recovery, provided that strict surgical indications are adhered to. Intervertebral surgery, with its shorter operative time and lower intraoperative blood loss, may offer additional perioperative advantages and serve as a viable option for MSTB management.
Keywords: multisegmental spinal tuberculosis, Clinical Characteristics, surgical treatment, efficacy evaluation, Mangement
Received: 08 Dec 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Yang, Gu, Qiang, Long, Le, Niu and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ningkui Niu, Department of Orthopedic, General Hospital of Ningxia Medical University Yinchuan, Ningxia Hui Autonomous Region, 750004, China, yinchuan, China
Jiandang Shi, Department of Orthopedic, General Hospital of Ningxia Medical University Yinchuan, Ningxia Hui Autonomous Region, 750004, China, yinchuan, China
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