MINI REVIEW article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1541471
This article is part of the Research TopicDietary Habits in Liver Health and Disease: Preclinical and Clinical StudiesView all 15 articles
Association between hypoglycaemia and poor clinical outcomes in hospitalised non-diabetic patients with liver cirrhosis:-A Narrative Review
Provisionally accepted
- 1Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, Australia
- 2The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
- 3Curtin University, Perth, Western Australia, Australia
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Hypoglycaemia is rarely highlighted as a complication that requires close monitoring in patients with chronic liver disease, despite substantial evidence of its occurrence in cirrhotic patients. This narrative review aims to evaluate whether hypoglycaemia in liver cirrhosis patients, irrespective of diabetes status, exacerbates complications and warrants targeted management strategies. Our analysis reveals that hypoglycaemia is prevalent in cirrhotic patients and is associated with increased mortality and complications compared to normoglycemic patients. Although literature in this topic is limited, our review suggests that early identification of high-risk liver disease patients and the implementation of novel, clinically relevant strategies to minimise hypoglycaemia may improve clinical outcomes and health-related quality of life as well as reduce morbidity and mortality. Further research will be required to validate thesel strategies.
Keywords: Hypoglycaemia, chronic liver disease, cirrhosis, complications, Clinical guidelines
Received: 07 Dec 2024; Accepted: 21 Apr 2025.
Copyright: © 2025 Govindarajan, CHEN, Zhang, Hu, Xu and Kuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dan Xu, Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, Australia
Ming Kuang, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong Province, China
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