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ORIGINAL RESEARCH article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1538654
This article is part of the Research Topic Advancing Cardiovascular Disease Understanding Through Metabolomics and Metabolic Regulation Networks View all 4 articles
Association between cardiovascular health and markers of liver function : a cross-sectional study from NHANES 2005-2018
Provisionally accepted- 1 Second Clinical Medical College, Nanchang University, Nanchang, Jiangxi Province, China
- 2 Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
Background: Cardiovascular health (CVH) has been associated with various systemic diseases. However, the relationship between CVH, as measured by Life's Essential 8 (LE8), and liver function markers in the general population remains poorly understood.Methods: This study analyzed data from 21,156 participants (aged ≥20) from the NHANES 2005-2018 to investigate the associations between CVH and liver function markers [alanine aminotransferase (ALT), aspartate aminotransferase (AST), gammaglutamyl transferase (GGT), alkaline phosphatase (ALP), albumin and AST/ALT ratio]. Linear regression models were used, along with a restricted cubic spline (RCS) to assess dose-response. Weighted quantile sum (WQS) regression and quantile gcomputation (QGC) analyses were employed to evaluate the association between CVH and liver function markers.Results: Linear regression analysis showed that each 1-point increase in CVH score was significantly associated with decreased levels of liver enzymes (ALT: -0.200 U/L
Keywords: No. 1, Minde Road. Donghu District, Nanchang, P.R CVH, Liver function, NHANES, Cross-sectional study, relationship
Received: 09 Dec 2024; Accepted: 20 Feb 2025.
Copyright: © 2025 Yu, Zhang, Liu, Guan, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ping Li, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China
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