REVIEW article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1538194
This article is part of the Research TopicNew Insights into Oxidative Medicine: Unraveling the Complexity of Oxidative Stress in Health and DiseaseView all 5 articles
Oxidative Stress Products and Managements in Atopic Dermatitis
Provisionally accepted
- 1School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China
- 2Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China
- 3Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects a significant portion of the global population, severely impacting the quality of life and causing physical and psychological distress of patients. Oxidative stress, resulting from an imbalance between oxidation and antioxidation activities, plays a pivotal role in the pathogenesis of AD. Monitoring oxidative stress products can offer valuable insights into the development of AD and highlight essential clinical and therapeutic effects. Additionally, evidence suggests that antioxidant strategies can alleviate or avert oxidative damage induced by free radicals and offer significant promise in the treatment of AD. In addition to directly utilizing natural products and nanomaterials for antioxidant interventions, these can also be incorporated into hydrogels, which help repair the skin barrier and support the sustained release of therapeutic agents. Furthermore, microneedles provide a minimally invasive method for delivering antioxidants to the deeper layers of the skin, enhancing treatment efficacy. This review aims to summarize the role of the oxidative stress in the pathogenesis of AD, focusing in the main oxidative products (DNA, protein, and lipid oxidation products), as well as antioxidant therapeutic approaches involving natural products, nanomaterials, hydrogels, and microneedles. Understanding these biomarkers and antioxidant therapy approaches provides important insights into the management of AD.
Keywords: atopic dermatitis, skin barrier, Oxidative Stress, Oxidation products, Oxidative stress marker, antioxidant therapy
Received: 20 Dec 2024; Accepted: 22 Apr 2025.
Copyright: © 2025 Luo, Hu, Zhou, Zhang, Wu and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yaguang Wu, Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, China
Jiaying Sun, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.