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CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1537160
This article is part of the Research Topic Infectious Diseases and Hematology: Diagnosis and Management - Volume II View all 9 articles
Successful salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: A case report
Provisionally accepted- 1 Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
- 2 Neurology Department, The First Affiliated Hospital of China Medical University, Shenyang, China
- 3 Department of Infectious Diseases, Peking Union Medical College Hospital (CAMS), Beijing, Beijing, China
We describe an acquired immunodeficiency syndrome (AIDS) patient who first exhibited chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently developed meningoencephalitis due to ganciclovir (GCV)-resistant cytomegalovirus (CMV) infection. The patient first presented with peripheral nervous system (PNS) symptoms, followed by central nervous system (CNS) symptoms. Based on auxiliary examinations, including cerebrospinal fluid (CSF) tests, electromyography (EMG), brain magnetic resonance imaging (MRI) and GCV drug resistance tests, the patient was diagnosed with CIDP and meningoencephalitis due to CSF GCV-resistant CMV.After the combined application of intravenous immunoglobulin treatment, corticosteroid treatment, antiretroviral therapy (ART), and adjusted anti-CMV treatment, the patient achieved persistent relief. This case underscores the importance of considering CMV as a common etiology of neurological disorders in AIDS patients. It also highlights the necessity of prompt drug resistance testing when anti-CMV therapy yields suboptimal responses.
Keywords: Cytomegalovirus, Meningoencephalitis, Chronic inflammatory demyelinating polyradiculoneuropathy, ganciclovir resistance, Acquired Immunodeficiency Syndrome
Received: 30 Nov 2024; Accepted: 17 Feb 2025.
Copyright: © 2025 Wang, Yang, Wen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Wen, Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China
Xinchao Liu, Department of Infectious Diseases, Peking Union Medical College Hospital (CAMS), Beijing, Beijing, China
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