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BRIEF RESEARCH REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1536148
Variations in Capillary and Serum Lactates Levels Based on Different Etiologies of Septic Patients in the Emergency Department
Provisionally accepted
Matteo Guarino 1
Benedetta Perna 1 Giacomo Maroncelli 1 Paolo Baldin 1 Chiara Donati 1 Francesco Luppi 1 Alice Eleonora Cesaro 1 Chiara Pesci 1
ANNA COSTANZINI 1
Martina Maritati 1 Paolo Clavenzani 2
Carlo Contini 1
Roberto De Giorgio 1* Michele Domenico Spampinato 1- 1 University of Ferrara, Ferrara, Italy
- 2 University of Bologna, Bologna, Emilia-Romagna, Italy
Sepsis is a life-threating and time-depending condition. This study examined the association between sepsis etiology and variations in capillary and serum lactate levels, neutrophilto-lymphocyte ratio, and diastolic shock index in emergency department patients.Methods: This study, conducted between 2021 and 2022 at the Emergency Department of Ferrara, included the following criteria: i) clinical suspect of infectious disease; ii) qSOFA ≥2; iii) age ≥18 years; iv) signed informed consent. Etiologies were: i) negative cultures (NC); ii) Gram positive (GP); iii) Gram negative (GN); iv) fungal infections (FI).Results: Among the 200 included patients, 104 (52.0%) had NC, 36 (18.0%) GP, 53 (26.5%) GN and 7 (3.5%) FI. CLs (p=0.006) and SLs (p<0.001) were different according to etiology being higher in GP infections. NLR (p=0.035) was higher in GN infections, while DSI (p=0.008) increased in FI.Mortality was not influenced by the etiology.All parameters differed according to sepsis etiology, thus improving early prediction of sepsis etiology and its pharmacological management.
Keywords: Diastolic shock index, etiology, Lactates, Neutrophil-to-lymphocyte ratio, Sepsis, septic shock
Received: 28 Nov 2024; Accepted: 04 Apr 2025.
Copyright: © 2025 Guarino, Perna, Maroncelli, Baldin, Donati, Luppi, Cesaro, Pesci, COSTANZINI, Maritati, Clavenzani, Contini, De Giorgio and Spampinato. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Roberto De Giorgio, University of Ferrara, Ferrara, Italy
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