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CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 |
doi: 10.3389/fmed.2025.1535961
Multiple Cryotherapy Sessions in Localized Darier's Disease: A Rare Clinical Presentation and Literature Review
Provisionally accepted- 1 Department Of Dermatology, Shenzhen University General Hospital, Shenzhen, China
- 2 Department of Burn and Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Shenzhen, China
- 3 Shenzhen Hospital, The University of Hong Kong, Shenzhen, Guangdong Province, China
Abstract： Darier's disease (DD), a rare hereditary acantholytic dermatosis with high penetrance but variable expressivity, has about 10% of its cases presenting as localized lesions, known as Localized Darier's Disease (LDD). To date, only a very small number of non-segmental LDD cases have been reported. This study reports a case of a 27-year-old Chinese male with LDD, who presented with yellow-brown papules and plaques on the inner side of the right thigh for one month. The diagnosis of localized keratosis follicularis was confirmed through dermatoscopic examination and histopathological assessment of the skin lesion. After repeated applications of cryotherapy combined with the use of emollients, while avoiding physical friction and sun exposure, the rash gradually subsided. The patient experienced no adverse reactions after treatment. The occurrence of LDD on the inner thigh, a relatively rare site, provides new insights into the affected areas of LDD, further expands the clinical manifestations of the disease, and offers valuable experience for clinicians in recognizing and managing LDD at different sites, aiding in the optimization of diagnostic and therapeutic strategies.
Keywords: Localized Darier's Disease, Cryotherapy, The inner thigh, Clinical manifestations, Therapeutic strategies Abbreviations: DD, darier's disease, ATP2A2, ATPase, Ca(++) transporting, cardiac muscle, slow-twitch 2, LDD, Localized Darier's Disease, SERCA2, sarcoplasmic/endoplasmic reticulum calcium ATPase type 2, ILVEN, inflammatory linear verrucous epidermal nevus
Received: 28 Nov 2024; Accepted: 13 Jan 2025.
Copyright: © 2025 Lyu, Wang, Guan, Ma and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Wang, Department Of Dermatology, Shenzhen University General Hospital, Shenzhen, China
Lyuxin Guan, Department of Burn and Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Shenzhen, China
Li Ma, Department Of Dermatology, Shenzhen University General Hospital, Shenzhen, China
Hao Li, Shenzhen Hospital, The University of Hong Kong, Shenzhen, 518053, Guangdong Province, China
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