94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Med.
Sec. Hematology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1534956
This article is part of the Research Topic Clinical prediction models in cancer through bioinformatics View all 5 articles
Age-related differences in primary central nervous system lymphomas based on the SEER database
Provisionally accepted
Tengjiao Lin 1 Ke Wang 2,3 Deyu Yang 2,3 Zhichao Li 2,3
Chaungjie Zheng 2 Xinrong Chen 2
Linzhu Zhai 1*- 1 The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- 2 Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
- 3 Lingnan Medical Research Centre, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
The aim of this study was to compare prognostic factors and survival outcomes in patients with primary central nervous system lymphoma (PCNSL).The Surveillance, Epidemiology, and End Results (SEER) database was queried for patients diagnosed with PCNSL between 2000 and 2019.Results: Between 2000 and 2019, a total of 5812 patients were diagnosed with PCNSL, of whom 2175 (37%) were ≤ 60 years old and 3637 (63%) were > 60 years old. The younger patients had a higher rate of being diagnosed with stage I-II, a higher rate of receiving chemotherapy and radiotherapy, a similar rate of receiving surgery, and a longer survival time. The most common histological subtype among PCNSL patients was diffuse large B-cell lymphoma (PCNS-DLBCL). Younger PCNS-DLBCL patients who received surgery and chemotherapy exhibited significantly improved overall survival (OS) and disease-specific mortality (DSM) and that African American patients were associated with poorer OS and DSM. Older patients receiving surgery, chemotherapy, and radiotherapy exhibited significantly improved OS and DSM, male and higher Ann Arbor stage were associated with poorer OS and DSM. We created a nomogram for PCNS-DLBCL to predict OS, with a C-index of 0.6749 in the younger cohort and 0.6676 in the older cohort. In the combined therapy analysis, chemotherapy combined with surgical resection had better OS and DSM in all patients.The two age-stratified cohorts significantly differed in terms of OS and independent influences on OS and DSM. Our constructed nomogram exhibited high accuracy in predicting OS in PCNS-DLBCL patients.
Keywords: primary central nervous system lymphoma, SEER, Population study, Treatment modality, nomogram
Received: 26 Nov 2024; Accepted: 11 Mar 2025.
Copyright: © 2025 Lin, Wang, Yang, Li, Zheng, Chen and Zhai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Linzhu Zhai, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.