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ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1534210
This article is part of the Research Topic New Concepts, Advances, and Future Trends in Clinical Research on Eye Diseases View all 23 articles
Laminar Keratoplasty with Acellular Porcine Corneal Stroma for the Treatment of Corneal Ulcers
Provisionally accepted
Yiming Hu 1 Lan Zhang 1
Qifang Jin 1*
Zhirong Lin 2* Lei Wu 3 Yao Zhu 4 Li Wu 1 Chenye Li 1 Youyang Ruan 5
Yunwei Hu 1 Feifei Wang 1- 1 Second Affiliated Hospital of Nanchang University, Nanchang, China
- 2 Eye Center, Xiamen University, Xiamen, Fujian Province, China
- 3 Rongcheng County People’s Hospital, Baoding, Hebei Province, China
- 4 Xichang People's Hospital, Xichang, Sichuan, China
- 5 School of Ophthalmology and Optometry, Nanchang University, Nanchang, Jiangxi Province, China
Objective: To investigate the efficacy and safety of acellular porcine corneal stroma for lamellar keratoplasty in the treatment of corneal ulcers.Methods:A total of 14 patients (14 eyes) diagnosed with corneal ulcers,who underwent lamellar keratoplasty with the acellular porcine stroma in the Second Affiliated Hospital of Nanchang University between June 2016 and May 2017, were recruited and followed up for at least 12 months.Postoperative visual acuity, epithelial recovery,graft transparency, recurrence rate of corneal ulcers, rate of graft rejection, corneal neovascularization, graft infection, secondary glaucoma, and graft melting were examined and analyzed.Results:All 14 patients(100%)who underwent lamellar keratoplasty with acellular corneal stroma successfully preserved the structure of the eyeballs.Visual acuity improved in 11 patients (78.5%).Graft rejection occurred in 1 patient(7.1%),while 2 patients(14.3%)developed recurrent corneal ulcers.Corneal vessel ingrowth was observed in 7 patients(50%)and 1 patient (7.1%)developed pseudopterygium.The average time of fully epithelial recovery was 3-7 days.Conclusions:Laminar keratoplasty using acellular porcine corneal stroma is an effective surgical alternative for the treatment of corneal ulcers.
Keywords: acellular porcine corneal stroma, laminar keratoplasty, Fungal corneal ulcer, viral corneal ulcer, Corneal graft
Received: 25 Nov 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Hu, Zhang, Jin, Lin, Wu, Zhu, Wu, Li, Ruan, Hu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qifang Jin, Second Affiliated Hospital of Nanchang University, Nanchang, China
Zhirong Lin, Eye Center, Xiamen University, Xiamen, Fujian Province, China
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