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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1534208
This article is part of the Research Topic Optimizing Medication Management in Older Adults: Addressing Polypharmacy, Deprescribing and Represcribing Challenges View all articles

Association between bone mineral density T-score and respiratory sarcopenia in older adults

Provisionally accepted
Ying Liu Ying Liu Yutong Guo Yutong Guo Yunyuan Kong Yunyuan Kong Jixiong Xu Jixiong Xu *
  • The First Affiliated Hospital of Nanchang University, Nanchang, China

The final, formatted version of the article will be published soon.

    Introduction: Respiratory sarcopenia, characterized by reduced respiratory muscle mass and strength, is underdiagnosed in older adults. This cross-sectional study aimed to investigate the association between bone mineral density (BMD) T-score and respiratory sarcopenia in a Chinese population. Methods: A total of 530 participants aged ≥60 years were recruited. Respiratory sarcopenia was diagnosed based on peak expiratory flow rate (PEFR) cutoffs. BMD was measured using dual-energy X-ray absorptiometry, and muscle mass was assessed using bioelectrical impedance analysis. Logistic regression models were used to analyze the association between BMD T-score and respiratory sarcopenia risk. Results: Participants with respiratory sarcopenia exhibited lower BMD T-score, appendicular skeletal muscle index, trunk muscle mass ratio, and lung function parameters compared to those without respiratory sarcopenia. The odds ratio (95% CI) for the lowest BMD T-score tertile with the risk of respiratory sarcopenia was 4.52(1.71 to 13.1) compared with the highest tertile. This association remained significant after adjusting for confounding factors.BMD T-score is significantly associated with an increased risk of respiratory sarcopenia in older adults. This finding highlights the importance of bone mass monitoring and early prevention strategies to reduce the incidence of respiratory sarcopenia.

    Keywords: Association, Bone Mineral Density, Older Adults, Risk, Respiratory Sarcopenia mass ratio, FBG, fasting blood glucose, ALT, glutamic pyruvic transaminase, HDL-C, high-density lipoprotein cholesterol, LDL-C, low-density lipoprotein cholesterol, CR, serum creatinine, ALT, alanine transaminase, BUN, serum blood urea nitrogen

    Received: 25 Nov 2024; Accepted: 23 Jan 2025.

    Copyright: © 2025 Liu, Guo, Kong and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jixiong Xu, The First Affiliated Hospital of Nanchang University, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.