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ORIGINAL RESEARCH article

Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1531777
This article is part of the Research Topic Advancing Atopic Dermatitis Management: Translational Research and Emerging Therapies View all articles

THE REGULATION OF DNA METHYLATION IN LESIONAL TISSUE IN CHILDREN WITH ATOPIC DERMATITIS

Provisionally accepted
Demet Kartal Demet Kartal 1*Hanefi Dirican Hanefi Dirican 2Mehmet Memis Mehmet Memis 3Serpil Taheri Serpil Taheri 4Eda Öksüm Solak Eda Öksüm Solak 1Salih Levent Cinar Salih Levent Cinar 1Murat Borlu Murat Borlu 1
  • 1 Department, Dermatology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye
  • 2 tokat city hospital, tokat, Türkiye
  • 3 Technology Transfer Office Application and Research Center, Bayburt University, Bayburt, Bayburt, Türkiye
  • 4 Experimental Research Center, Erciyes University, Kayseri, Kayseri, Türkiye

The final, formatted version of the article will be published soon.

    Background: Genetic and epigenetic mechanisms have been shown to play a role in the pathogenesis of atopic dermatitis (AD). However, the role of genes involved in the establishment of DNA methylation, has not been shown yet.Methods: 15 AD patients and 15 healthy volunteers in the pediatric age group were included in this study. The mRNA gene expression level of 8 different genes involved in DNA methylation regulation were examined in blood and tissue samples.The mRNA expression levels of DNMT3A genes were significantly increased, while mRNA expression levels of DNMT3B, TET1 and TET2 genes were statistically significantly reduced in tissues with lesions of patient compared to the control group. It was determined that the mRNA expression levels of DNMT1, DNMT3A and TET3 genes increased, while the mRNA expression levels of the DNMT3L and TET1 genes were found to be decreased in the blood of the patients.The results indicate that the DNA methylation picture in patients is hypermethylated, especially in the lesional tissue. The data we obtained may contribute to the unknown epigenetic regulation of AD disease and to the development of new diagnosis and treatment options.

    Keywords: atopic dermatitis, DNA Methylation, TET1-2 and DNMT gene expression, epigenetic, Pediatric atopic dermatitis

    Received: 20 Nov 2024; Accepted: 03 Feb 2025.

    Copyright: © 2025 Kartal, Dirican, Memis, Taheri, Solak, Cinar and Borlu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Demet Kartal, Department, Dermatology, Faculty of Medicine, Erciyes University, Kayseri, 38030, Türkiye

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.