Association between Weekend warriors and MASLD: A cross-sectional study of the NHANES Database

博扬 苏 松 王 ^* 铁军 刘 ^* Yan Leng ZhiYuan Liu ^* Lu Liu ^* Zhuang Xiong ^*

• The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China

The incidence of metabolic dysfunction associated steatotic liver disease (MASLD) continues to escalate annually, threatening the public's physical and mental health, and leading to a huge economic burden on healthcare, and Physical Activity(PA) is one of the effective means of preventing MASLD. However, epidemiologic evidence on the association between weekend warriors (WWs) exercise mode and MASLD is inconsistent. The main objective of this study was to further observe the association between weekend warriors and the prevalence of MASLD through the NHANES database.The study included a total of 4671 participants from the National Health and Nutrition Examination Survey (NHANES) database. PA questionnaires were used to assess participants' Physical Activity patterns, Vibration controlled transient elastography (VECT) was used to assess the degree of hepatic steatosis, and other data were used to diagnose MASLD. Three different models were constructed to compare the associations between different exercise patterns and the MASLD prevalence by logistic regression. And to compare the difference between Regular Activity(RA) and WWs in MASLD prevalence.There is a clear association between the involvement of WWs or RA participants and the lower prevalence of MASLD. In the final adjusted model, participants with a weekend warrior physical activity pattern (OR: 0.511, 95% CI: 0.373-0.701, p: 0.00.6) and participants in the regular activity population (OR: 0.621, 95% CI: 0.512-0.754, p: 0.00.3) were significantly lower than those in the inactive and under-exercised populations in terms of the risk ratio, in the final adjusted model and was statistically significant. Using the regular activity population as a reference, the risk of MASLD prevalence in the weekend warrior group (OR: 0.857, 95% CI:0.548-1.339,p: 0.516) However, no statistically meaningful disparity was observed between the two groups.In summary, our results show that WWs' activity patterns and their risk of MASLD are significantly correlated and that they can improve MASLD with benefits comparable to those of RA. This provides additional options for individuals with MASLD who are unable to meet the recommended criteria in the exercise guidelines, as well as treatment options for clinicians.