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ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1525575
This article is part of the Research Topic Managing Cardiac Arrest View all articles
The association between ABO blood type and outcomes following sudden cardiac arrest: a multicenter observational study
Provisionally accepted
Jiun-Wei Chen 1 Ren-Jie Tsai 1
Cheng-Yi Fan 1
Sih-Shiang Huang 1 Ching-Yu Chen 2
Chi-Hsin Chen 1 Jia-How Chang 1
Edward Pei-Chuan Huang 1 Wei-Tien Chang 3
Chih-Wei Sung 1*- 1 National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan
- 2 National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
- 3 National Taiwan University Hospital, Taipei, Taiwan
Background: ABO blood type has been associated with various disease outcomes, but its relationship with outcomes in patients with sudden cardiac arrest (SCA) remains unexplored.This was a retrospective analysis of adult out-of-hospital cardiac arrest patients with SCA treated at three major branches of the National Taiwan University Hospital between January 2016 and July 2023. The variables examined for their possible influence on the neurological and survival outcomes of patients with SCA were sociodemographic characteristics, pre-existing diseases, resuscitation events, and blood type. The results of a multivariable logistic regression were reported as adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Neurological outcomes were determined by the Cerebral Performance Category [CPC] scale at hospital discharge.Results: No significant differences were found in the prevalence of each blood type between those who survived and those who did not or between those with good (CPC 1-2) or poor (CPC 3-5) neurological outcomes. There was no significant association between survival and blood type; however, patients with blood type AB had a higher probability of good neurological outcomes than those with blood type O (aOR: 1.98, 95% CI: 1.02-3.83, p = 0.042). A sensitivity analysis of the data from patients with aseptic etiologies also showed a significantly higher likelihood of good neurological outcomes among those with blood type AB (aOR: 2.21, 95% CI: 1.12-4.35, p = 0.023).ABO blood type is not associated with survival in patients with SCA, but blood type AB is associated with better neurological outcomes than type O.
Keywords: ABO blood type, Cardiac arrest, neurological outcome, Sudden cardiac arrest, Survival
Received: 09 Nov 2024; Accepted: 25 Mar 2025.
Copyright: © 2025 Chen, Tsai, Fan, Huang, Chen, Chen, Chang, Huang, Chang and Sung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chih-Wei Sung, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan
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