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BRIEF RESEARCH REPORT article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1525538

Impending sepsis-induced coagulopathy (SIC) is associated with increased disease severity in SIC-nega;ve pa;ents: A secondary analysis of a prospec;ve exploratory study

Provisionally accepted
Thomas Schmoch Thomas Schmoch 1,2*Patrick Möhnle Patrick Möhnle 3Christian Nusshag Christian Nusshag 4Manuel Feißt Manuel Feißt 5Markus Weigand Markus Weigand 6Thorsten Brenner Thorsten Brenner 1
  • 1 Department of Anesthesiology and Intensive Care Medicine, Essen University Hospital, Essen, North Rhine-Westphalia, Germany
  • 2 Hôpital Kirchberg, Luxembourg, Luxembourg
  • 3 Department of Transfusion Medicine, Cell Therapeutics and Hemostaseology, LMU Munich University Hospital, Munich, Bavaria, Germany
  • 4 Department of Nephrology, Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Baden-Württemberg, Germany
  • 5 Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Baden-Württemberg, Germany
  • 6 Department of Anesthesiology, Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Baden-Württemberg, Germany

The final, formatted version of the article will be published soon.

    Due to intensive crosstalk between the coagulaUon and immune systems, coagulaUon disorders are an integral part of the disturbed host response to infecUon that defines sepsis. These so-called sepsis-induced coagulopathies (SIC) are associated with increased morbidity and mortality. However, we sUll do not know enough about the prevalence and risk factors of SIC in different paUent groups. Here we present a secondary analysis of a prospecUve, observaUonal study. The objecUves of this secondary analysis were (1) to esUmate the prevalence of SIC at sepsis onset, (2) to assess the SIC prevalence throughout the intensive care unit (ICU) stay using a pre-described modified SIC score, and (3) to evaluate the associaUon between SIC and morbidity and mortality. The SIC prevalence at sepsis onset was 15.0% (95% confidence interval [CI] 9.3%-23.3%). Twenty-four addiUonal paUents who were SIC negaUve at sepsis onset developed SIC according to the modified SIC score during their ICU stay. In total, we esUmated that 39.0% (95% CI 30.0%-48.8%) of paUents experienced relevant SIC during their ICU stay. SepUc shock, a high lactate level, and a high SequenUal Organ Failure Assessment (SOFA) score at sepsis onset in SIC-negaUve paUents were associated with SIC development during the course of the disease. These findings need to be verified in lager cohorts and may represent a starUng point for the development of a new screening tool for the idenUficaUon of paUents with sepsis at high risk of developing SIC.

    Keywords: Sepsis, Sepsis-induced coagulopathy, sepsis-associated coagulopathy, septic shock, Scoring

    Received: 09 Nov 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Schmoch, Möhnle, Nusshag, Feißt, Weigand and Brenner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Thomas Schmoch, Department of Anesthesiology and Intensive Care Medicine, Essen University Hospital, Essen, 45147, North Rhine-Westphalia, Germany

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