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ORIGINAL RESEARCH article
Front. Med.
Sec. Nuclear Medicine
Volume 12 - 2025 |
doi: 10.3389/fmed.2025.1525334
This article is part of the Research Topic Methods and Strategies for Integrating Medical Images Acquired from Distinct Modalities View all articles
Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: A cardiac magnetic resonance feature tracking research
Provisionally accepted- 1 Other, Dalian, China
- 2 Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Objective: To explore the effects of comorbid burden on left cardiac myocardial function in patients without organic heart disease, and to construct prediction models of myocardial function damage.Methods: Eighty-two healthy subjects and 198 patients with comorbid burden who had normal left ventricular ejection fraction (LVEF) were recruited. Comorbid burden included hypertension, type 2 diabetes mellitus (T2DM), and dyslipidemia. According to the type of disease, patients with comorbid burden were divided into comorbid burden<2 and comorbid burden≥2. Cardiac magnetic resonance feature tracking (CMR-FT) was used to measure myocardial strain parameters.Results: After adjusting, left atrial (LA) reservoir strain (P=0.011), and conduit strain (P<0.001) were significantly lower in patients with comorbid burden≥2. Left ventricular (LV) global longitudinal strain (P<0.001) and global radial strain (P=0.010) were decreased in both comorbid burden<2 and comorbid burden≥2 groups. LV global circumferential strain (P=0.006) was reduced in the comorbid burder≥2 group. Comorbid burden combined with male sex, postprandial blood glucose (PBG), and fasting blood glucose (FBG) were excellent predictors of LV myocardial function damage (AUC=0.848). Comorbid burden combined with male sex was a fair predictor of LA myocardial function damage (AUC=0.651).CMR-FT can detect left-sided myocardial function damage in patients with comorbid burden but without organic heart disease prior to the decrease in LVEF. Comorbid burden combined with male sex, PBG, and FBG showed excellent predictive ability for LV 2 myocardial function damage. Comorbid burden combined with male sex showed a fair predictive ability for LA myocardial function damage.
Keywords: CMR-FT, comorbid burden, myocardial function damage, myocardial strain, Hypertension, type 2 diabetes mellitus, Dyslipidemia
Received: 09 Nov 2024; Accepted: 24 Jan 2025.
Copyright: © 2025 Qu, Bai, Lyu, Yin, Zhang, Zhao and Mei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
XiaoFeng Qu, Other, Dalian, China
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