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REVIEW article

Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1525205
This article is part of the Research Topic Mechanisms and Novel Treatments of Muscle Wasting View all articles

Lipid Peroxidation and Sarcopenia: Molecular Mechanisms and Potential Therapeutic Approaches

Provisionally accepted
Yifan Lu Yifan Lu 1Yang Shu Yang Shu 2,3Chengyin Lu Chengyin Lu 1Zhiqiang Luo Zhiqiang Luo 1Jingrui Wang Jingrui Wang 2,3Hui Xiong Hui Xiong 3Wangyang Li Wangyang Li 1*
  • 1 The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, China
  • 2 Hunan University of Chinese Medicine, Changsha, Anhui Province, China
  • 3 The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China

The final, formatted version of the article will be published soon.

    Sarcopenia is an age-related condition characterized by the progressive loss of skeletal muscle mass and strength. With the global aging population, its incidence is rapidly increasing. Lipid peroxidation is a critical biochemical process that generates reactive oxygen species (ROS), leading to the destruction of muscle cell structure and function. It plays a pivotal role in the onset and progression of sarcopenia. This review summarizes the mechanisms by which lipid peroxidation contributes to sarcopenia, with a focus on its regulatory effects on cell membrane damage, mitochondrial dysfunction, and cell death. In addition, we discuss the protective role of antioxidant factors such as GPX4 (glutathione peroxidase 4) and antioxidant peptides like SS peptides in mitigating lipid peroxidation and delaying the progression of sarcopenia.Finally, the potential of various strategies, including natural compounds, supplements, natural extracts, and lifestyle interventions, in inhibiting lipid peroxidation and promoting muscle health is explored.

    Keywords: Sarcopenia, Lipid Peroxidation, Oxidative Stress, Antioxidants, therapeutic strategies

    Received: 09 Nov 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Lu, Shu, Lu, Luo, Wang, Xiong and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wangyang Li, The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.