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SYSTEMATIC REVIEW article

Front. Med.
Sec. Gene and Cell Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1522318

Comparison of the Risk of Obesity in the FTO rs9939609 Genotype in a Multiethnic Group in Asia Systematic Review and Meta-Analysis

Provisionally accepted
Rony Abdi Syahputra Rony Abdi Syahputra 1*Donna Pratiwi Donna Pratiwi 2Miko Sidartha Miko Sidartha 3Elvan Wiyarta Elvan Wiyarta 4Wayan Agustinus Harimawan Wayan Agustinus Harimawan 5Ni Made Dwi Lestari Ni Made Dwi Lestari 6Bonglee Kim Bonglee Kim 7Nurpudji Astuti Taslim Nurpudji Astuti Taslim 8Trina Ekawati Tallei Trina Ekawati Tallei 9Fahrul Nurkolis Fahrul Nurkolis 10
  • 1 University of North Sumatra, Medan, Indonesia
  • 2 Ternate Regional General Hospital, Ternate, Indonesia
  • 3 Bhayangkara Police Hospital Ternate, Ternate, Indonesia
  • 4 University of Indonesia, Depok, West Java, Indonesia
  • 5 Prof.dr.I.G.N.G Ngoerah General Hospital, Bali, Indonesia
  • 6 Bali Mandara General Hospital, Bali, Indonesia
  • 7 Kyung Hee University, Seoul, Republic of Korea
  • 8 Hasanuddin University, Makassar, South Sulawesi, Indonesia
  • 9 Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • 10 Sunan Kalijaga State Islamic University Yogyakarta, Yogyakarta, Special Region of Yogyakarta, Indonesia

The final, formatted version of the article will be published soon.

    Aim: This study aims to examine the comparative risk of obesity in the FTO rs9939609 genotype in multiethnic groups in Asia, considering that obesity has become a global disease. Data synthesis: Data searches were carried out in several electronic databases: PubMed, Scopus, Google Scholar, ScienceDirect, ClinicalTrials.gov and NCBI. The search involved a combination of keywords related to genetics and obesity risk. Pooled Odds Ratio (POR) with 95% CI was calculated based on the pooled data. Review Manager (RevMan) 5.4.1 were used to analyze the data. Results: From 18 studies, the results of the dominant genetic model AA vs TT showed POR 95%Cl=1.95 (1.36-2.80); P<0.00001, in AA vs TA genetic recessive model, POR 95%Cl =1.31 (1.07-1.60); P=0.002, then the final model of TA vs TT codominance genetic model obtained POR 95%Cl=1.52 (1.04-2.23); P<0.00001. The overall risk of bias was low.From this research, it was found that there was a comparison of the genotype that had a higher risk of obesity, namely the AA genotype in multiethnic groups in Asia.

    Keywords: obesity risk, FTO gene rs9939609, Asia, Multiethnic groups, AA genotype

    Received: 04 Nov 2024; Accepted: 22 Jan 2025.

    Copyright: © 2025 Syahputra, Pratiwi, Sidartha, Wiyarta, Agustinus Harimawan, Lestari, Kim, Taslim, Tallei and Nurkolis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rony Abdi Syahputra, University of North Sumatra, Medan, Indonesia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.