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REVIEW article

Front. Med.
Sec. Precision Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1522223
This article is part of the Research Topic Nanomedicine Targeting Central Nervous System View all 3 articles

Targeted Drug Delivery in Neurodegenerative Diseases: The Role of Nanotechnology

Provisionally accepted
Rupal Dhariwal Rupal Dhariwal 1MUKUL JAIN MUKUL JAIN 1*Abhayveer Singh Abhayveer Singh 2Bhavik Jain Bhavik Jain 3Pankaj Kumar Pankaj Kumar 1*Dr. Mohd Tariq Dr. Mohd Tariq 1*Yaser Rafiq Mir Yaser Rafiq Mir 4Devvret Verma Devvret Verma 5Khemraj Deshmukh Khemraj Deshmukh 1Virendra Kumar Virendra Kumar 6Tabarak Malik Tabarak Malik 7*
  • 1 Parul University, Waghodia, Gujarat, India
  • 2 Chitkara Institute of Engineering & Technology, Chitkara University, Punjab, Punjab, India
  • 3 Chitkara University (Himachal Pradesh), Baddi, India
  • 4 Baba Ghulam Shah Badshah University, Rajauri, Jammu and Kashmir, India
  • 5 Graphic Era University, Dehradun, Uttarakhand, India
  • 6 Marwadi University, Rajkot, Gujarat, India
  • 7 Jimma University, Jimma, Oromia, Ethiopia

The final, formatted version of the article will be published soon.

    Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as a promising approach to enhance drug delivery across physiological barriers, particularly the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (B-CSFB). By employing nanoparticles, this research aims to address critical challenges in the diagnosis and treatment of conditions such as Alzheimer's, Parkinson's, and Huntington's diseases. The multifactorial nature of these disorders necessitates innovative solutions that leverage nanomedicine to improve drug solubility, circulation time, and targeted delivery while minimizing off-target effects. The findings underscore the importance of advancing nanomedicine applications to develop effective therapeutic strategies that can alleviate the burden of neurodegenerative diseases on individuals and healthcare systems.

    Keywords: Nanotherapeutics, neurodegeneration, targeted delivery, small molecules Font: Not Bold, Complex Script Font: Not Bold, Pattern: Clear (White) Font: Not Bold, Complex Script Font: Not Bold Formatted: Normal, Space Before: Auto

    Received: 04 Nov 2024; Accepted: 06 Jan 2025.

    Copyright: © 2025 Dhariwal, JAIN, Singh, Jain, Kumar, Tariq, Mir, Verma, Deshmukh, Kumar and Malik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    MUKUL JAIN, Parul University, Waghodia, Gujarat, India
    Pankaj Kumar, Parul University, Waghodia, Gujarat, India
    Dr. Mohd Tariq, Parul University, Waghodia, Gujarat, India
    Tabarak Malik, Jimma University, Jimma, Oromia, Ethiopia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.