SYSTEMATIC REVIEW article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1521587
Comprehensive Overview of Antibody Drug-Related Clinical Studies in Gynecology Insights from ClinicalTrials.gov
Provisionally accepted
Xiaoling Zhou
Xiao LiFan LaiWei ChenCongrong ZhouYi DengTao Wang
Shasha Xing
Haoyang DiaoMi Tang
Wenmei Guo
Erdan Luo*- Chengdu Women and Children’s Central Hospital, Chengdu, China
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Antibodies have been widely used globally over the past decade and play an increasingly important role in modern medicine. Notably, significant advancements have been achieved in the realm of gynecology, particularly in gynecological cancers. This study endeavors to present a thorough overview of antibody-related drugs clinical studies in gynecology registered on ClinicalTrials.gov, which focuses on the basic characteristics of trials, geographical distribution, administration routes, indications, and targets. The analysis indicates a rising prevalence of antibody-drug conjugates (ADCs), bispecific antibodies, and Fc-fusion proteins.This study will develop new ideas for future research on antibodies in gynecology.
Keywords: Clinicaltrials.gov, Antibodies, Gynecology, Antibody-drug conjugates, bispecific antibodies, Fc-fusion proteins, administration route 1
Received: 02 Nov 2024; Accepted: 18 Apr 2025.
Copyright: © 2025 Zhou, Li, Lai, Chen, Zhou, Deng, Wang, Xing, Diao, Tang, Guo and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Erdan Luo, Chengdu Women and Children’s Central Hospital, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.