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CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 |
doi: 10.3389/fmed.2025.1518583
Case Report: Efficacy of tofacitinib in the treatment of generalized pustular psoriasis
Provisionally accepted- 1 Guizhou University of Traditional Chinese Medicine, Guiyang, China
- 2 The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China
Generalized pustular psoriasis (GPP) is a rare and potentially life-threatening autoimmune inflammatory skin disease. Tofacitinib is a non-selective first-generation Janus kinase (JAK) inhibitor. Currently, both domestic and international reports regarding the use of tofacitinib mainly have primarily focused on the treatment of psoriasis vulgaris and psoriatic arthritis. As GPP is a rare skin disease, reports on the use of tofacitinib in the treatment of GPP are rare. This report presents a case of severe GPP effectively treated with tofacitinib. This case suggests that the nonselective JAK inhibitor, which has a strong anti-inflammatory effect, could be an effective treatment option for cases of acute exacerbation of GPP, with a good safety profile.
Keywords: generalized pustular psoriasis, Tofacitinib, JAK inhibitors, case report, Psoriasis
Received: 28 Oct 2024; Accepted: 29 Jan 2025.
Copyright: © 2025 Wang, Mei, He and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ting Tang, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China
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