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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1514894
This article is part of the Research Topic Advances in the Pathogenesis and Treatment of Osteoporosis: From Bench to Bedside View all 7 articles

Risk factors for new vertebral fractures after percutaneous vertebroplasty or percutaneous kyphoplasty in the treatment of osteoporotic vertebral compression fractures

Provisionally accepted
Wencheng Yang Wencheng Yang 1*Xuping Lin Xuping Lin 1Yanfang Yang Yanfang Yang 2*Wanhan Su Wanhan Su 1*Tianpei Chen Tianpei Chen 1*Xiuming Wu Xiuming Wu 1*Xiaomeng Wang Xiaomeng Wang 1*Kaiwei Zou Kaiwei Zou 1*Qingjun Liu Qingjun Liu 3*Chunhui Huang Chunhui Huang 1*
  • 1 Department of Orthopedics, Longyan First Hospital, Longyan, China
  • 2 Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian Province, China
  • 3 The Affliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    This study aims to conduct a prospective analysis of patients with osteoporotic vertebral compression fractures (OVCF) who underwent percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP), and further analyze the risk factors for new vertebral fracture following treatment. Methods A prospective study was conducted from November 2020 to March 2022 at the First Hospital of Longyan City to select patients with OVCF who underwent treatment in the Department of Spinal Surgery.Data collection during the follow-up period focused on various factors that could potentially be associated with new vertebral fractures after PVP/PKP procedures.Patients were divided into two groups based on whether they experienced new vertebral fractures within two years after discharge: the new fracture group (n=186) and the nonfracture group (n=64), and statistical analysis was conducted accordingly. Results All cases were followed up for 12 to 24 months, with an average of 14.7 months.Differential analysis revealed that age, diabetes, hemoglobin (HB), total protein (TP), serum albumin (ALB), b-C-terminal telopeptide of type I collage ( β -CTX), 25hydroxyvitamin D (25-OH-D3), number of fractured vertebrae, bone mineral density (BMD), regular exercise after discharge, anti-osteoporosis treatment after discharge, cross-sectional area (CSA), and fatty degeneration ratio (FDR) were associated with new vertebral fractures (all P < 0.05). Multivariate analysis showed that age (OR = 1.519, P = 0.032), diabetes (OR = 3.273, P = 0.048), and FDR (OR = 1.571, P = 0.027) were positively associated with the occurrence of new vertebral fractures, while bone mineral density (OR = 0.108, P = 0.044), 25-OH-D3 (OR = 0.871, P = 0.032), CSA (OR = 0.564, P = 0.009), regular postoperative exercise (OR = 0.259, P = 0.025), and osteoporosis treatment (OR = 0.291, P = 0.045) were negatively associated with the occurrence of new vertebral fractures. Conclusion Patients with osteoporosis fractures who are older, have poor glycemic control, lower bone mineral density, lower levels of 25-OH-D3, weaker paraspinal muscles, and higher fat infiltration are at increased risk of new vertebral fractures after undergoing PKP/PVP. On the other hand, maintaining regular physical activity and adhering to osteoporosis treatment can help prevent new vertebral fractures.

    Keywords: Osteoporotic vertebral compression fractures, senior citizen, New vertebral fractures, Percutaneous vertebroplasty, Percutaneous kyphoplasty, Risk factors

    Received: 21 Oct 2024; Accepted: 08 Jan 2025.

    Copyright: © 2025 Yang, Lin, Yang, Su, Chen, Wu, Wang, Zou, Liu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wencheng Yang, Department of Orthopedics, Longyan First Hospital, Longyan, China
    Yanfang Yang, Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian Province, China
    Wanhan Su, Department of Orthopedics, Longyan First Hospital, Longyan, China
    Tianpei Chen, Department of Orthopedics, Longyan First Hospital, Longyan, China
    Xiuming Wu, Department of Orthopedics, Longyan First Hospital, Longyan, China
    Xiaomeng Wang, Department of Orthopedics, Longyan First Hospital, Longyan, China
    Kaiwei Zou, Department of Orthopedics, Longyan First Hospital, Longyan, China
    Qingjun Liu, The Affliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China
    Chunhui Huang, Department of Orthopedics, Longyan First Hospital, Longyan, China

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