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CASE REPORT article

Front. Med.
Sec. Pathology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1514349

A Case of Massive Hematoma: Reflections on Hypermobile Ehlers-Danlos Syndrome

Provisionally accepted
Yu Xiong Yu Xiong *QingHua Liu QingHua Liu Ganhua Zeng Ganhua Zeng Chenyang Xu Chenyang Xu
  • Ganzhou People's Hospital, Ganzhou, China

The final, formatted version of the article will be published soon.

    Ehlers-Danlos Syndrome (EDS) refers to a group of connective tissue disorders characterized by significant clinical and genetic variability, affecting multiple systems in the body. Classified as a rare disease, EDS includes 14 subtypes, all marked by joint hypermobility, skin extensibility, and tissue fragility. These subtypes present with a wide range of clinical manifestations and severities, including frequent joint dislocations, scoliosis, arterial dissections, and organ ruptures. Hypermobile EDS (hEDS) is the most common subtype, with newly established clinical diagnostic guidelines. In this case, a patient presented with minor hemoptysis over 8 hours, and a chest CT scan revealed a massive hematoma in the left lower lung. Due to the complexity and varied presentations of EDS, misdiagnosis is common. This report shares our experience with diagnosis and treatment in this case, highlighting the importance of increasing awareness for improved survival outcomes.

    Keywords: Pulmonary hematoma, case report, hypermobile Ehlers-Danlos syndrome (hEDS), Hemoptysis, Thoracic Surgery

    Received: 21 Oct 2024; Accepted: 07 Jan 2025.

    Copyright: © 2025 Xiong, Liu, Zeng and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yu Xiong, Ganzhou People's Hospital, Ganzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.